Sex specific effects of irisin on the skeleton.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 42270587.
- Also identified by DOI 10.1038/s41413-026-00542-4 and PMC identifier 13254336.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Irisin, the circulating protein derived from cleavage of fibronectin type III domain containing protein 5 (FNDC5) has attracted considerable attention regarding its positive effects on a number of organs/tissues such as fat, brain, and heart. However, effects on bone can appear to be either positive or negative depending on context and sex. Sex differences have also been described in Alzheimer's disease also emphasizing sex differences in response to irisin. Here in this review, we outline and focus on the effects of irisin on osteoblasts, osteoclasts, and osteocytes, murine models, and human studies. The consideration of sex effects is necessary especially in the context of irisin serving as a therapeutic.
Medical subject headings
- Fibronectins
- Bone and Bones
- Sex Characteristics