Charting human cellular senescence in aging and disease.
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- Record sourced from PubMed, PMID 42276030.
- Also identified by DOI 10.1016/j.cell.2026.05.028.
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Abstract
Cellular senescence comprises diverse cell states emerging across human tissues during aging and disease. Integrating single-cell and spatial multi-omics with AI-driven analyses enables systematic mapping of senescent cell heterogeneity ("senotypes"), revealing tissue-specific programs and microenvironmental interactions. These advances provide frameworks for biomarker discovery and development of targeted senotherapeutic strategies.
Medical subject headings
- Cellular Senescence
- Aging