Cysteine's metabolic fork: Sulfur partitioning shapes T cell function.
basic_science · Level V
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- Record sourced from PubMed, PMID 42276031.
- Also identified by DOI 10.1016/j.cell.2026.05.011.
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Abstract
T cells live or die by their metabolism, yet one nutrient can serve very different ends. In this issue of Cell, Kelly et al. show that cysteine's sulfur is partitioned between glutathione and iron-sulfur cluster synthesis. This routing drives CD8<sup>+</sup> T cell proliferation, effector function, and anti-tumor immunity.
Medical subject headings
- Cysteine
- Sulfur
- CD8-Positive T-Lymphocytes
- T-Lymphocytes