SEMPLR: an R package for transcription factor binding prediction.

Kenney, Grace E; Sherpa, Rintsen N; Burgess, Jeremy D; Boyle, Alan P; Phanstiel, Douglas H · Bioinformatics · 2026

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Abstract

SEMPLR is an R package that predicts transcription factor binding and variant effects using SNP Effect Matrices (SEMs), providing efficient, genome-wide scoring, enrichment testing, and visualization tools for comprehensive analysis of regulatory sequences. Available on GitHub at https://github.com/grkenney/SEMPLR and on Bioconductor at https://bioconductor.org/packages/release/bioc/html/SEMPLR.html. Supplementary data are available at Bioinformatics online.