A Practical Reference for Stereotactic Radiosurgery Planning for Intracranial Indications.

Meng, Ying; Mashiach, Elad; Donahue, Bernadine; Bernstein, Kenneth; Silverman, Joshua S; Golfinos, John; Sulman, Erik; Kondziolka, Douglas · Neurosurgery · 2026

review · Level V

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Abstract

Stereotactic radiosurgery evolved from the desire to achieve highly precise and accurate target ablation using radiation energy. Over the past 3 decades, the range of indications for stereotactic radiosurgery has expanded significantly, making it a valuable treatment option-and often a first-line approach-for various intracranial conditions, including benign and malignant brain tumors, vascular malformations, and functional disorders. This narrative review offers a comprehensive, yet not exhaustive, overview of the current evidence, technical considerations, and areas of nuance and controversy regarding these indications and dose selection. It serves as a quick reference guide for neurosurgeons and radiation oncologists working in this field. In addition, tables are included that detail the indications, expected results, dose prescriptions, and anticipated outcomes, assisting clinicians in both clinical settings and procedural planning.