Rsk4 Mediates Brain FGF19 Signaling to Constrain Diet-Induced Obesity in Mice.
basic_science · Level V
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- Record sourced from PubMed, PMID 42301138.
- Also identified by DOI 10.2337/db25-0859.
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Abstract
Ribosomal S6 kinase 4 (Rsk4) is predominantly expressed in hypothalamic neurons. Rsk4 is negligible for maintaining energy homeostasis in mice. Loss of Rsk4 promotes diet-induced obesity and related metabolic disorders in mice. Rsk4 is required for central fibroblast growth factor-19 to reduce body weight in obese mice.