Redefining radiotherapy: the gut as an active target in Immuno-Oncology.
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- Record sourced from PubMed, PMID 42301752.
- Also identified by DOI 10.1158/1078-0432.CCR-26-1177.
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Abstract
Low-dose intestinal irradiation challenges the long-standing view of the gut as a radiation-sensitive organ to avoid. Clinical and mechanistic data suggest that targeted exposure of the small intestine within a 1 to 3 Gy window can remodel the microbiome and enhance systemic antitumor immunity.