Divergent PET Tracer Avidity in Synchronous Sarcomatoid Carcinoma With Osteosarcomatous Differentiation and Adenocarcinoma of the Prostate: Insights From Dual-Tracer 68 Ga-PSMA and 18 F-FDG PET/CT Imaging.
case_report · Level V
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- Record sourced from PubMed, PMID 42302393.
- Also identified by DOI 10.1097/RLU.0000000000006576.
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Abstract
A 76-year-old man with mildly elevated prostate-specific antigen (PSA, 5.44ng/mL) and a PI-RADS 5 lesion on multiparametric MRI underwent dual-tracer PET/CT. 68 Ga-PSMA PET/CT revealed focal intense uptake in one prostatic lobe, while 18 F-FDG PET/CT demonstrated avid uptake in the contralateral lobe. Histopathology confirmed synchronous high-grade prostatic adenocarcinoma (Gleason 9) and sarcomatoid carcinoma with osteosarcomatous differentiation. This discordant dual-tracer pattern highlights the complementary role of PSMA and FDG PET/CT in detecting molecularly divergent synchronous prostatic malignancies.
Medical subject headings
- Prostatic Neoplasms
- Positron Emission Tomography Computed Tomography
- Adenocarcinoma
- Fluorodeoxyglucose F18
- Edetic Acid
- Oligopeptides