Oversimplified immunology is holding biomaterials back.

Stelzel, Jessica L; Schneck, Jonathan P; Mao, Hai-Quan; Doloff, Joshua C · Nat Rev Bioeng · 2025

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Abstract

Immune responses are complex, often defying rigid classifications. Instead of interpreting results according to reductionist categories, researchers should rely on comprehensive single-cell data to guide analysis and should remain open to unexpected immunological complexity.