Fibrin, from blood to bone: a review.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 42305573.
- Also identified by DOI 10.1016/j.bonr.2026.101925 and PMC identifier 13266232.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Fibrin is principally involved in blood coagulation and hemostasis. Its structure, abundance and turnover are reciprocally related to blood flow. Decreased abundance of fibrin in afibrinogenemic or hemophilic patients leads to bone disorders such as bone cysts or hemarthroses. Fibrin accumulation in growing children with chronic disease leads to osteoarthritis and physeal disruption. Despite its clear role in bone disorders; the underlying mechanisms are not clearly understood. Bone formation and hemostasis is mediated by osteocyte mechanosensitivity involving plasma membrane disruption, calcium signaling cascade. Fibrin is related to mechanotransduction in platelets and recently in mitochondrial mechanosensing in macrophages, however its role in bone mechanobiology is not elucidated. This review underlines the link of fibrin and bone pathophysiology and emphasizes the gap of knowledge between fibrin function during healing and mechanobiology of bone homeostasis. This review proposed an original perspective to better understand bone loss, repair and formation, that could open the path to further investigations to adapt innovative therapeutic strategies.