Diffuse Splenic Uptake on 99m Tc MDP Bone Scintigraphy Secondary to Transfusion-Related Hemosiderosis : Correlation With MRI Findings.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 42307418.
- Also identified by DOI 10.1097/RLU.0000000000006580.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
A 70-year-old woman with a past medical history of breast cancer is undergoing surveillance. She also had a history of repeated blood transfusions for refractory anemia caused by treated marrow metastatic disease. Laboratory tests showed elevated AST (50 U/L) and ALT (115 U/L). 99m Tc MDP bone scintigraphy revealed intense diffuse splenic uptake. No splenic calcifications or infarcts were found on contrast-enhanced CT. MRI demonstrated signal dropout on in-phase sequences and marked T2 hypointensity of the spleen and liver, without focal splenic lesions, suggesting transfusion-related secondary hemosiderosis. Iron overload should be considered when diffuse splenic uptake is observed on bone scintigraphy.
Medical subject headings
- Hemosiderosis
- Spleen
- Magnetic Resonance Imaging
- Technetium Tc 99m Medronate
- Bone and Bones
- Transfusion Reaction