Biomimetic Catalytic System Mimicking Immune Defense and Tissue Healing for Dynamic Treatment of Skin Infections.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 42307438.
- Also identified by DOI 10.1021/acs.nanolett.6c01094.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Managing skin infections requires both pathogen eradication and tissue regeneration, yet current therapeutics rarely address these sequential needs. Here, we designed a biomimetic catalytic system (MBC) to recapitulate the dynamic, dual-phase functionality of the innate immune response. In the infectious microenvironment, MBC mimics neutrophil-mediated killing by using CeO<sub>2</sub> nanoparticles (NPs) and Br ions to exert haloperoxidase-like activity, generating HBrO from endogenous H<sub>2</sub>O<sub>2</sub> to eliminate MRSA biofilms. Upon infection clearance, the system autonomously transitioned to a healing phase. CeO<sub>2</sub> NPs switch to macrophage-like antioxidant functions, scavenging reactive oxygen species, resolving inflammation, and restoring immune homeostasis. In three murine infection models of MRSA-infected wounds, pressure ulcers, and subcutaneous abscesses, MBC achieves comprehensive therapeutic efficacy.