Maternal trans-vaccenic acid shapes neonatal T cell development and early-life immune imprinting.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 42313977.
- Also identified by DOI 10.1126/science.aea4041.
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Abstract
How maternal nutrition influences neonatal immune development and imprinting through breastfeeding remains largely unclear. We report that maternal supplementation with trans-vaccenic acid (TVA), the predominant naturally occurring trans-fatty acid in human breast milk, promoted neonatal T cell development in mice. Neonates fed by mothers on a TVA-enriched diet showed an expanded naïve cluster of differentiation 4 (CD4<sup>+</sup>) T cell population and enhanced adaptive immunity against infection. TVA reprogrammed neonatal naïve CD4<sup>+</sup> T cells through a G protein-coupled receptor-CCCTC-binding factor axis and promoted T helper cells (Th1)-skewing by cooperating with the transcription factor TBX21. Early-life exposure to maternal TVA via breastfeeding supported long-lasting antiviral immunity in adulthood. Our findings establish the multifaceted benefits of maternal nutrition and breastfeeding via TVA in promoting infant immune homeostasis and protective immunity.
Medical subject headings
- Adaptive Immunity
- CD4-Positive T-Lymphocytes
- Maternal Nutritional Physiological Phenomena
- Oleic Acids
- Th1 Cells