The biology of jumbo phages.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 42321167.
- Also identified by DOI 10.1038/s41467-026-74333-0 and PMC identifier 13282480.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Jumbo bacteriophages are bacterial viruses with double-stranded DNA genomes exceeding 200 kb. These viral giants feature exceptionally large virions, expansive genetic repertoires, and in some cases, remarkable eukaryotic-like traits. Jumbo phages challenge long-standing notions of phage simplicity, redefining the boundaries of what a phage can be. In this Review, we examine the biology of jumbo bacteriophages, highlighting their diversity, evolutionary origins, distinctive morphologies and lifecycles, complex interactions with bacterial hosts, and their potential for biotechnology and therapy, with a focus on, but not limited to, the Chimalliviridae phages.
Medical subject headings
- Bacteriophages