IL1RAP-expressing myeloid-stromal networks represent a therapeutic vulnerability to improve chemoimmunotherapy sensitivity in pancreatic cancer.
Where this comes from
- Record sourced from PubMed, PMID 42325091.
- Also identified by DOI 10.1172/jci.insight.202487.
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Abstract
IL1RAP blockade remodels the pancreatic cancer microenvironment, reduces myeloid immunosuppression, restores memory-like CD8+ T cell states, and enhances chemoimmunotherapy sensitivity.
Medical subject headings
- Pancreatic Neoplasms
- Immunotherapy
- Interleukin 1 Receptor Antagonist Protein