Atomic-Scale Full-Size Engineering of Platinum Nanozymes Enables High-Efficiency Catalytic Therapy.
basic_science · Level V
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- Record sourced from PubMed, PMID 42328814.
- Also identified by DOI 10.1021/acsnano.6c06389.
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Abstract
Metal particle size has a significant influence on the activity of nanozymes, yet size-dependent nanozymatic catalysis under the same metal loadings in full scale (from single atom, cluster to nanoparticle) is a challenging task and has been rarely reported. Herein, porous SiO<sub>2</sub> nanoflower surface-confined Pt-based nanozymes with the same metal loadings but different particle sizes were rationally designed and synthesized for antibacterial and cascade catalytic tumor therapy. The particle size-activity relationship is well established, presenting a volcanic curve, and the Pt<sub>NC</sub>/SiO<sub>2</sub> nanocluster (NC) nanozyme exhibits optimized peroxidase-like activity and bactericidal efficacy compared with SAzyme and nanozyme. Furthermore, a synergistic therapeutic platform (Lap@Pt<sub>NC</sub>/SiO<sub>2</sub>) is constructed through the adsorption of the prodrug β-lapachone (Lap), achieving high-efficiency cascade enzymatic catalysis for tumor therapy thereby. The cluster nanozymes not only present optimized activity during the full-size engineering but also demonstrate great potential in next-generation antibacterial and tumor catalytic therapy.