Macrophage-fibroblast signaling networks identified by single-cell RNA sequencing in juvenile systemic sclerosis.

Shethji, Aneri; Hutchins, Theresa; Sanyal, Anwesha; Liu, Tianhao; Chen, Wei; Torok, Kathryn S · JCI Insight · 2026

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Abstract

<style type="text/css">a { text-decoration: none; color: #464feb; } tr th, tr td { border: 1px solid #e6e6e6; } tr th { background-color: #f5f5f5; } </style> Single‑cell analysis of juvenile systemic sclerosis skin reveals altered fibroblast-macrophage interactions that may drive fibrosis and identify pathways relevant to pediatric disease.

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