The three-dimensional perspective of CAR-T cell therapy in autoimmune diseases.
review · Level V
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- Record sourced from PubMed, PMID 42335674.
- Also identified by DOI 10.1016/j.ebiom.2026.106341.
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Abstract
Chimeric antigen receptor T (CAR-T) cell therapy has achieved remarkable success in haematological malignancies, ushering in the era of adoptive cell therapy. In recent years, CAR-T cell therapy has been progressively explored in autoimmune diseases (AIDs), with the goal of inducing deep immune remodelling and durable drug-free remission in selected patients. This review evaluates CAR-T cell therapy in AIDs through three clinically relevant dimensions: depth, breadth, and length. We use this framework to discuss therapeutic efficacy, immune remodelling mechanisms, disease spectra, target selection, long-term persistence and safety, with the aim of supporting more precise and controllable clinical development.