Enhanced IGFL1 translation in response to IL-1β is controlled by distinct 3'UTR elements.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 42348514.
- Also identified by DOI 10.1371/journal.pone.0342288 and PMC identifier 13298950.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Translation is a crucial regulatory mechanism involved in several diseases, including cancer, where pro-inflammatory conditions within the microenvironment have been shown to modulate the translation of specific mRNAs. In the present study, we focused on the regulation of insulin growth factor-like family member 1 (IGFL1) in MCF7 breast cancer cells in response to pro-inflammatory IL-1β and observed an induction of both transcription and translation. We characterized the 3' untranslated region as regulatory hub for the post-transcriptional regulation and identified a distinct G-rich region to confer the IL-1β-dependent translational increase. Our study therefore provides new insights into the translation regulation of IGFL1 in the context of an inflammatory tumor microenvironment.
Medical subject headings
- Interleukin-1beta
- 3' Untranslated Regions
- Protein Biosynthesis
- Insulin-Like Peptides