Excessive vascular integrity restricts anti-tumor immunity.
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- Record sourced from PubMed, PMID 42349379.
- Also identified by DOI 10.1016/j.cell.2026.05.034.
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Abstract
Vessel normalization aims to correct the abnormal vasculature in the tumor to improve drug delivery and immune control. In this issue of Cell, Wang et al. identify an immune-excluding vasculature in small-cell lung cancer, where excessive vessel integrity drives immune desertification, and propose "reverse normalization" to restore immune access and overcome immunotherapy resistance.