TXNIP Is Positioned as a Key Mediator of Hyperglycemia-Induced Vascular Senescence.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 42371657.
- Also identified by DOI 10.2337/db25-1093.
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Abstract
This study identifies the carbohydrate-responsive element-binding protein as the direct transcriptional activator of TXNIP in vascular smooth muscle cells under conditions of hyperglycemia. Aorta-specific TXNIP knockdown demonstrates therapeutic potential by alleviating arterial stiffness and attenuating atherosclerotic plaque in diabetic mice. Pharmacologic inhibition of TXNIP or activation of AKT ameliorates the senescent phenotype, highlighting a druggable pathway in diabetic vasculopathy.