Virologic Outcomes After LA ART Initiation with and without Viremia in Two Large U.S. Clinic Cohorts.

Spinelli, Matthew; Heise, Megan J; Glidden, David V; Grochowski, Janet; Oskarsson, Jon; Niles-Carnes, Larisa; Ochieng, Eudiah; Lora, Meredith et al. · Clin Infect Dis · 2026

prospective_cohort · Level II

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Abstract

Long-acting cabotegravir/rilpivirine supports virologic suppression among people with HIV (PWH) facing adherence challenges. In two large U.S. cohorts(n=1,070), 96% of viremic PWH achieved virologic suppression at a 4-week median. However, blips/failure were more frequent among PWH initiating with viremia, underscoring the need for careful monitoring and optimization of long-acting treatment.