Pulmonary monocyte kinetics in healthy volunteers and subjects with inflammatory arthritis.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 42373324.
- Also identified by DOI 10.1136/thorax-2025-224226.
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Abstract
Monocytes are central to innate and adaptive immunity, regulating tissue homeostasis and inflammation. However, data on their steady-state biodistribution in healthy humans are limited. We developed a non-invasive method to track radiolabelled autologous monocytes. Monocytes showed distinct intravascular transit kinetics vs neutrophils, with 45 min recovery of 47% for neutrophils vs 7% for monocytes (p=0.008), indicating predominant distribution in marginated pools. In patients with psoriatic and rheumatoid arthritis but no documented lung disease, we observed preferential early retention of monocytes in the lungs (transit half-life 25.2 min vs 14.2 min; p=0.008) compared with healthy volunteers, with reduced intravascular recovery in patients with rheumatoid arthritis (4.3% vs 12%; p=0.0043). These findings provide the first direct evidence of human monocyte pulmonary transit kinetics, systemic biodistribution and fate in health and inflammatory disease, advancing understanding of in vivo monocyte biology.