Diabetic Wound Healing Enabled by a Tri-Functional MAX Phase via Cu Doping.
basic_science · Level V
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- Record sourced from PubMed, PMID 42374632.
- Also identified by DOI 10.1002/adhm.202505611.
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Abstract
Due to complex pathological features and difficulty in healing wounds caused by diabetes, effective therapeutic agents and strategies remain elusive. Herein, we report on the development of Cu-doped single-phase Nb<sub>2</sub>(Sn<sub>0.7</sub>Cu<sub>0.3</sub>)C MAX as a tri-functional therapeutic material for diabetic wound healing. The stable Nb-C lattice facilitates near-infrared plasmonic photothermal therapy, physically disrupting bacterial structures. Controllable Cu<sup>2</sup> <sup>+</sup> release mimics endogenous metal ion signaling, disrupting TCA metabolism to induce bacterial cuproptosis. Meanwhile, Cu<sup>2</sup> <sup>+</sup> also promotes regenerative macrophage phenotype and reduces excessive neutrophil activation. The Nb 4d-C 2p orbital hybridization simulates VEGF functionality to mediate angiogenesis. In vivo experiments demonstrate that Nb<sub>2</sub>(Sn<sub>0.7</sub>Cu<sub>0.3</sub>)C promotes rapid infection clearance, initiating the wound healing process. This is followed by the restoration of immune homeostasis, ultimately leading to effective angiogenesis. Our Nb<sub>2</sub>(Sn<sub>0.7</sub>Cu<sub>0.3</sub>)C overcomes the limitations of single-targeted therapeutic agents, capable of simultaneously addressing issues such as infection control, inflammation resolution, and tissue regeneration.