SGLT2 inhibitors enhance ketogenesis by acting as allosteric activators of the mitochondrial enzyme HMGCS2.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 42383358.
- Also identified by DOI 10.1172/JCI192333.
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Abstract
SGLT2 inhibitors boost ketone production by directly activating a liver enzyme, revealing a new mechanism that may contribute to their heart and kidney benefits.
Medical subject headings
- Sodium-Glucose Transporter 2 Inhibitors
- Hydroxymethylglutaryl-CoA Synthase
- Ketone Bodies
- Mitochondria