Treatment-refractory hypothyroidism: Don't just increase the dose.
Level V
Where this comes from
- Record sourced from PubMed, PMID 42386364.
- Also identified by DOI 10.3949/ccjm.93a.25100.
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Abstract
Causes of treatment-refractory hypothyroidism include nonadherence, interference from food or drugs, gastrointestinal disorders, and increased levothyroxine turnover. A practical, stepwise diagnostic approach starts with a detailed history, followed by gastrointestinal and ancillary evaluations. Assay interference and other confounding conditions should also be considered. A trial of levothyroxine formulations other than oral tablets may be useful in select cases.
Medical subject headings
- Hypothyroidism
- Thyroxine