Outside the niche: Gut microbiota relay psychological stress to hematopoietic stem cell dysfunction.

Zhou, Haiyan; Wei, Yuxi; Zhang, Dachuan · Cell Stem Cell · 2026

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Abstract

Hematopoietic stem cells integrate local and systemic cues to sustain blood homeostasis. In this issue of Cell Stem Cell, Tian et al.<sup>1</sup> uncover a stress-responsive brain-gut-bone marrow axis that drives aging-like dysfunction of hematopoietic stem cells.

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