Lupus Lymphadenitis With Intense Pentixafor Avidity But Absent FDG Uptake.
case_report · Level V
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- Record sourced from PubMed, PMID 42410755.
- Also identified by DOI 10.1097/RLU.0000000000006397.
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Abstract
A 33-year-old woman presented with intermittent fever for 1 month, accompanied by pancytopenia and multiple enlarged lymph nodes in the bilateral neck, axillary and para-iliac regions on ultrasound. With informed consent, the patient was enrolled in a clinical trial comparing 18F-FDG and 68Ga-Pentixafor PET/CT for lymph node lesions. In contrast to the negative 18F-FDG PET/CT findings, 68Ga-Pentixafor PET/CT showed high tracer uptake in these lymph nodes. Subsequent cervical lymph node excision biopsy revealed reactive lymphoid hyperplasia; combined with elevated anti-ds-DNA, anti-SS-A, and anti-RNP titers, lupus lymphadenitis was diagnosed. After antisystemic lupus erythematosus therapy, the lymph nodes regressed significantly.
Medical subject headings
- Fluorodeoxyglucose F18
- Positron Emission Tomography Computed Tomography
- Lymphadenitis
- Lupus Erythematosus, Systemic
- Coordination Complexes