Fibrous Dysplasia With 99m Tc-FAPI Uptake in a Patient Under Long-term Antiresorptive Therapy.
case_report · Level V
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- Record sourced from PubMed, PMID 42410757.
- Also identified by DOI 10.1097/RLU.0000000000006109.
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Abstract
We report a rare case of a 40-year-old woman with longstanding craniofacial fibrous dysplasia involving the right maxilla, orbital cavity, and fronto-parietal bones. The patient underwent partial maxillary debulking 7 years ago for cosmetic reasons and orbital decompression 3 years ago, and is currently on long-term antiresorptive therapy. Bone scintigraphy with 99mTc-MDP showed multiple sites of increased osteoblastic activity. 99mTc-FAPI SPECT/CT also revealed focal uptake in craniofacial and other lesions, indicating active fibroblast proliferation. This is the first reported case of 99mTc-FAPI uptake in fibrous dysplasia, suggesting its value in evaluating fibrotic bone lesions.
Medical subject headings
- Craniofacial Fibrous Dysplasia