FGF21 connects ER stress to sulfide signaling to enhance cellular resilience.
basic_science · Level V
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- Record sourced from PubMed, PMID 42413473.
- Also identified by DOI 10.1016/j.cmet.2026.06.009.
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Abstract
Fibroblast growth factor 21 (FGF21) is a stress-induced endocrine hormone that regulates metabolism. Grandl et al. show that FGF21, through its receptor β-klotho (KLB), enhances sulfide signaling and hydrogen sulfide production, strengthening the unfolded protein response and integrated stress response to promote stress resilience, metabolic adaptation, and potentially healthy aging.
Medical subject headings
- Fibroblast Growth Factors
- Signal Transduction
- Hydrogen Sulfide
- Endoplasmic Reticulum Stress
- Sulfides