A liver phosphatase reprograms gut stem cells to drive hyperglycemia.
basic_science · Level V
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- Record sourced from PubMed, PMID 42413475.
- Also identified by DOI 10.1016/j.cmet.2026.06.006.
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Abstract
Why is fatty liver disease associated with hyperglycemia? In this issue, Ye, Wan, Liu, Deng, Zhang et al.<sup>1</sup> propose an unexpected mechanism: hepatic alkaline phosphatase released from diseased liver suppresses intestinal stem cell differentiation into GLP-1-secreting L-cells. This study reveals a new pathogenic route of liver-intestine communication.