Glycerol activates tissue-nonspecific alkaline phosphatase for temperature and bone homeostasis.
Where this comes from
- Record sourced from PubMed, PMID 42413477.
- Also identified by DOI 10.1016/j.cmet.2026.06.016.
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Abstract
Tissue-nonspecific alkaline phosphatase (TNAP) has roles in bone mineralization and the futile creatine cycle, which fuels uncoupling protein 1 (UCP1)-independent thermogenesis in adipocytes. Hussain and colleagues provide evidence for allosteric activation of TNAP by glycerol and demonstrate that this activation is necessary for both bone mineralization and thermogenesis.
Medical subject headings
- Alkaline Phosphatase
- Homeostasis
- Glycerol
- Bone and Bones