Adipose Tissue Overexpression of Nicotinamide Phosphoribosyltransferase Prevents Metabolic Dysfunction in Obese Mice via Extracellular Vesicles.
basic_science · Level V
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- Record sourced from PubMed, PMID 42418158.
- Also identified by DOI 10.2337/db25-0914.
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Abstract
NAD+ is an essential cofactor for many metabolic reactions. Nicotinamide phosphoribosyltransferase (NAMPT) is an important enzyme in NAD+ biosynthesis, and diminished adipocyte NAD+ and NAMPT have been implicated in metabolic dysfunction. Mice with adipocyte NAMPT overexpression (ANOV) were protected from diet-induced metabolic dysfunction, including adipose tissue inflammation, glucose intolerance, and hepatic steatosis. Extracellular vesicles from ANOV mice improved glucose tolerance in obese mice. Compared with wild-type mice, adipose tissue extracellular vesicles from ANOV mice exhibited marked changes in lipid and metabolite cargoes.