Hyperacute Progression of Sinonasal NUT Carcinoma After Pembrolizumab-Based Treatment: A Case Report.
case_report · Level V
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- Record sourced from PubMed, PMID 42420203.
- Also identified by DOI 10.1002/lary.70733.
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Abstract
This case report describes hyperacute destructive progression of sinonasal NUT carcinoma with new osseous metastasis shortly after pembrolizumab-based immunochemotherapy. The clinical course highlights the importance of early NUT testing, proactive systemic surveillance, cautious interpretation of immunotherapy response, and timely consideration of BET inhibition or clinical trial referral.