Sensitivity of Measles rRT-PCR Testing During an Outbreak in Persons without Rash.

Gressick, Kimberly; Gretsch, Stephanie; Filardo, Thomas D; DeJonge, Peter M; Borah, Brian F · Clin Infect Dis · 2026

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Abstract

During the 2024 Chicago measles outbreak, 120 real-time reverse-transcription polymerase chain reaction (rRT-PCR) tests were performed on 117 symptomatic persons with measles exposure, but without rash; test sensitivity was 78% (7 true positive). After an initial negative test, providers should maintain suspicion of measles and repeat testing as symptoms progress.