Neural circuits for valence updating in social memory.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 42424460.
- Also identified by DOI 10.1126/science.adx8231.
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Abstract
Social animals recognize familiar conspecifics and selectively avoid harmful ones. As social relationships shift, continuous updating of social valence is essential, yet the underlying neural mechanisms remain unclear. Here, by artificially transforming a previously neutral conspecific into an aggressive one, we show that valence updating depends on enhanced synaptic connectivity and physiological changes within the hippocampal ventral CA1 (vCA1)-basolateral amygdala (BLA)-nucleus accumbens (NAc) circuit. Following defeat, social memory engram neurons in the vCA1 strengthened their connections with BLA neurons carrying negative valence. The vCA1-BLA-NAc neural circuit flexibly regulates adaptive social behaviors.
Medical subject headings
- Memory
- CA1 Region, Hippocampal
- Nucleus Accumbens
- Social Behavior
- Basolateral Nuclear Complex
- Neural Pathways