Bridging omics and physiology to build multimodal clocks of human aging.

Koyuncu, Seda; Petrovic, Dunja; Vilchez, David · Cell · 2026

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Abstract

Human aging is a heterogeneous, multi-system process that spans molecular, tissue, and physiological decline. In this issue of Cell, Li et al. integrate clinical data, multi-omics, and organ-associated signatures to construct a multi-layer framework for quantifying biological aging across scales.