FLASH radiation therapy mitigates immunogenic and pro-fibrotic transcriptomic responses in healthy lung tissue.
basic_science · Level V
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- Record sourced from PubMed, PMID 42431271.
- Also identified by DOI 10.1016/j.radonc.2026.111689.
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Abstract
To investigate why FLASH-radiation therapy (RT) minimises lung damage, we performed bulk RNA-sequencing at 24 h and 2 weeks post-irradiation. Unlike conventional dose-rate RT, FLASH did not induce acute chemokine enrichment associated with NFKB1 upregulation and prevented sustained transcriptional activation of genes involved in macrophage activation, chemotaxis, and differentiation.