Rutin-Doped Hybrid Nanoparticles: Effect of the Molecular Doping Density on <i>T</i><sub>1</sub> Relaxivity and Their Application in Targeted Magnetic Resonance Imaging of Malignant Tumors.
basic_science · Level V
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- Record sourced from PubMed, PMID 42446001.
- Also identified by DOI 10.1021/acs.nanolett.6c02191.
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Abstract
Molecular doping is a promising strategy to tune the performance such as relaxivity and targeting ability of magnetic resonance imaging (MRI) nanocontrast agents. Herein, hybrid nanoparticles of amphiphilic manganese complex (MnL) and DSPE-PEG were first prepared, and it was found that a higher DSPE-PEG doping density reduced size and increased <i>T</i><sub>1</sub> relaxivity. Then, rutin (Ru) doping further transformed hybrid nanoparticle morphology from spherical to snowflake-like, decreased size, and enhanced <i>T</i><sub>1</sub> relaxivity by increasing the number of coordinated water molecules (<i>q</i>) and water exchange rate (1/τ<sub>M</sub>). Ru-doped hybrid nanoparticles (MnL/Ru NP5) with a MnL/DSPE-PEG/Ru mass ratio of 1/2/4 exhibited the highest <i>T</i><sub>1</sub> relaxivity and good stability and biosafety and were selected for <i>in vivo</i> tumor-targeted MRI. MnL/Ru NP5 shows promise for MRI of H22 tumors thanks to its effective glucose transporters (GLUTs)-mediated tumor-cell-targeting ability. Our molecular doping strategy provides a potential way for the structural design of high-performance hybrid nanocontrast agents.