Ventilation parameters during Advanced Life Support in cardiac arrest (CAvent): A multicentre observational cohort study.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 42448221.
- Also identified by DOI 10.1016/j.resuscitation.2026.111203.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Despite the critical role of ventilation during CPR, insights into the procedure are limited. This study aimed to describe and compare ventilation parameters across different ventilation modes and airway modalities during CPR with manual ventilation. The Cardiac Arrest ventilation study (CAvent) was a multicentre, prospective observational cohort study in adult patients with cardiac arrest across five Advanced Life Support systems in Sweden and the Netherlands. Ventilation parameters were measured with a portable pneumotachograph and capnography device. Parameters were compared between ventilation modes (synchronous versus asynchronous) and airway modalities (bag-valve-mask (BVM), supraglottic airway device (SAD), and endotracheal tube (ETT)) using mixed-effects regression models. Between May 2019 and August 2025, 241 cardiac arrest patients yielded 28 120 ventilations for analysis. Ventilations caused an expiratory tidal volume of 186 (95% CI 104-260) ml in synchronous BVM, 395 (316-475) ml in synchronous SAD, 333 (227-437) ml in asynchronous SAD, and 404 (371-435) ml in asynchronous ETT ventilations. Asynchronous ETT ventilation was associated with the longest time of airway pressure >30 cmH<sub>2</sub>O at 5.8 (5.1-6.4) s·min<sup>-1</sup> and highest peak inspiratory pressure, 51.0 (95% CI 48.7-53.1) cmH<sub>2</sub>O. Ventilation parameters during CPR vary substantially across manual ventilation modes and airway modalities. Specifically, BVM ventilations demonstrate limited efficacy, SAD ventilations yield consistent tidal volumes and pressures across modes, with leakage increasing over time, while asynchronous ETT ventilation generates high airway pressures. This highlights a need for standard measurement of ventilation parameters in CPR-related studies and clinical practice.