From matching to facilitation: Reframing AI's role in clinical trial enrollment.

Yaacov, Adar; Levi, Einat; Peled, Nir · Patterns (N Y) · 2026

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Abstract

Yaacov, Levi, and Peled argue that AI-powered clinical trial matching has achieved near-expert technical accuracy yet fails to increase patient enrollment because the dominant bottleneck is systemic-involving logistics, workflow misalignment, and consent burden-not informational. They propose reframing AI's role from matching engine to trial facilitation system.