Bacteriophage therapy of Mycobacterium abscessus mastoiditis.

Becken, Bradford; Lauer, Michael J; Russell, Daniel A; Garlena, Rebecca A; Cristinziano, Madison; Abad, Lawrence; Dedrick, Rebekah M; Jacobs-Sera, Deborah et al. · Clin Infect Dis · 2026

case_report · Level V

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Abstract

We describe a case of a child with macrolide-resistant Mycobacterium abscessus who initially had clinical improvement on a dual β-lactam regimen but continued to have positive cultures. Suitable phages active against the bacterial strain were identified, administered both systemically and directly to the ear, and were associated with microbiological remission.