Growth of PIK3CA-driven cerebral cavernous malformations does not require microbiome stimulation.

Li, Lun; Lightle, Rhonda; Ali, Bader; Sader, Georgeio; Shenkar, Robert; Polster, Sean P; Marchuk, Douglas A; Burkhardt, Jan-Karl et al. · JCI Insight · 2026

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Abstract

We find that the microbiome plays a critical role in the formation of cerebral cavernous malformations in neonatal but not adult life.

Medical subject headings