Inherited salt retention is associated with increased IL-17 responses and autoimmunity.

Rauf, Muhammad Atif; Agarwal, Sanskriti; Baker, Rebecca R; Steeden, Jennifer; Petrosino, Alfredo; Kiliaris, Maria; Unwin, Robert; Siew, Keith et al. · JCI Insight · 2026

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Abstract

Patients with Familial Hyperkalaemic Hypertension (inherited salt retention) have increased sodium stores, dysregulated immunity, and are more prone to developing autoimmune disease.

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