A novel multifunctional split-type porous biomimetic absorbable mPLA-HA lamina for spinal posterior column reconstruction following laminectomy.

Abstract

The correction of severe spinal deformities often requires osteotomy procedures such as laminectomy. This compromises the structural integrity of the spinal posterior column and may lead to complications including spinal instability, spinal cord exposure, and failure of bone graft fusion. A persistent clinical challenge is how to reconstruct the lamina to restore biomechanical stability while simultaneously protecting the spinal cord. Currently, no standardized artificial lamina repair material is available, and traditional metallic or single-component bioabsorbable materials cannot adequately balance biocompatibility, mechanical support, and physiological healing. To address this need, we designed and fabricated a novel multifunctional split-type porous biomimetic absorbable modified PLA-HA lamina (MSPBA mPLA-HA lamina). In a sheep laminectomy model, the implant-bone interface bone volume fraction in the experimental group reached 74.6% and was significantly higher than that in the control group, while the mechanical stiffness of the reconstructed lamina was comparable to that of native sheep lumbar laminae. These findings suggest that the implant can support lamina reconstruction and that its porous architecture may provide a structural basis for reducing local epidural compression. As a bioactive absorbable construct, the MSPBA mPLA-HA lamina may represent a promising strategy for more physiologically compatible spinal posterior column reconstruction.