VDAC1 O-GlcNAcylation Promotes mtDNA Release and Activates ZBP1-Dependent Neuroinflammation in Diabetic Retinopathy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 42474271.
- Also identified by DOI 10.2337/db26-0151.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The limited efficacy of anti-VEGF therapy in diabetic retinopathy (DR) highlights the importance of nonvascular mechanisms in disease progression. Hyperglycemia is a key driver of neuroinflammation in DR. Hyperglycemia results in VDAC1 O-GlcNAcylation in Müller glia, leading to mtDNA release and ZBP1 activation, thereby linking metabolic stress to neuroinflammation in DR. Targeting VDAC1-mediated mtDNA release or using vitreous mtDNA as a biomarker may enable earlier diagnosis and novel therapeutic strategies for DR.