Ligand relay catalysis enables asymmetric migratory dearomative annulation of N-heteroarenes.
basic_science · Level V
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- Record sourced from PubMed, PMID 42477342.
- Also identified by DOI 10.1038/s41467-026-75769-0.
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Abstract
Chiral N-spiroheterocycles are privileged yet synthetically challenging scaffolds for ligands, functional materials, and drug discovery. Here we show a cobalt-catalyzed asymmetric migratory dearomative annulation of electron-deficient N‑heteroarenes for their construction. The success of this transformation hinges on a dynamic ligand relay catalysis strategy, wherein two distinct ligands work in tandem: one facilitates a 1,4-cobalt/hydride shift, and the other governs the enantioselective dearomative annulation, delivering chiral N-spiroheterocycles with high efficiency and selectivity.