Prognostic Value of Aspergillus-Specific T Cells in Invasive Pulmonary Aspergillosis Among Patients with Hematologic Malignancies.
case_series · Level IV
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- Record sourced from PubMed, PMID 42487611.
- Also identified by DOI 10.1093/infdis/jiag356.
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Abstract
In the OPTIFIL study that included 39 patients with localized invasive pulmonary aspergillosis complicating hematological malignancies, Aspergillus-specific IFNγ-producing T cells were detectable in 41% of the patients and predicted better 6-weeks outcomes, while their absence correlated with uncontrolled disease. Lymphopenia was the main limitation to Aspergillus ELISpot assay interpretation.