UTR-ly unexpected: RNA chaperones tame intrinsically disordered proteins.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 42492491.
- Also identified by DOI 10.1016/j.cell.2026.06.023.
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Abstract
How do cells ensure that complex, multidomain proteins fold correctly? Luo et al. reveal a self-contained solution. The 3' UTR of an mRNA co-translationally chaperones the protein it encodes, preventing intrinsically disordered regions from making inappropriate contacts. This functionality, localized to mesh-like condensates, challenges Anfinsen's dogma and opens therapeutic possibilities.
Medical subject headings
- Molecular Chaperones
- Intrinsically Disordered Proteins
- 3' Untranslated Regions