Neurodegenerative Diseases and Sleep Disorders: The Bidirectional Relationship.

Desai, Karan M; Thakkar, Mayur D; Somaiya, Tanvee S; Thomas, Davis C · Med Clin North Am · 2026

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Abstract

Neurodegeneration is mostly irreversible and progressive. Neurodegenerative diseases (NDDs) represent a large group of disorders that have varied clinical and pathologic representations. These include Alzheimer's disease, Parkinson's disease, vascular dementia, and amyotrophic lateral sclerosis, among others. A common factor in all these NDDs is sleep disorders (SDs). NDDs and SDs are bidirectional. Screening for SDs should be an integral part of a workup of NDDs. Management of one can improve the prognosis of the other.

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